When biological makeup is at its finest, the molecules of the body interact with one another. The synchronicity of biological systems or organs reveal the matter that organs communicate with one another. Past research has shown the organs have internal cell structures that communicate with one another, which are in fact communicated to the spleen and then revealed by the immune system. “The resulting cell–cell interaction network predicted frequent crosstalk between structural cells and haematopoietic cells under homeostasis.” (Krausbruger et al) Within Karusbruger, the RNA profiles showed that proteins are constructed regularly in mouse structural cells which revealed the immune response within those mice. However, this article shows the importance of the immune response once organ communication is subpar. What we haven’t shown yet in research is that organs communicate just as cells do according to research at the cellular level by Krausbruger. The spleen is one organ that stands out because its function is to signal to the body that the organs are communicating subpar.
When the balance of the systems is off, the human genome reveals its innate potential to harvest a upregulated response according to Krausbruger et al. According to Krausbruger, “…we found evidence of an epigenetically encoded immune potential under homeostatic conditions, and the affected genes were preferentially upregulated in response to an immunological challenge induced by systemic viral infection.” Biological systems can upregulate responses due to the inherent potential of the epigenome and this results in an immune response when organs do not communicate with one another as well as they should. There are implications from past immune research about the order in which an immune response begins based on the upregulation of the thymus and bone marrow sending out T and B cells, implying that one organ may be affected before another sending the biological systems’ communication into a less orderly framework than before.
When systems fall subpar, then the public’s health falls under similar disarray. The pandemic response gives us this example as an epidemic starts with just one infected person transmitting a weaker support response to the next. When public health is under strain, the body begins its cohesion repair system by getting the T and B cells to fight the foreign body as we know it already. Then, once the fight is over, the organs continue to communicate with one another appropriately as before and public health cohesion finds its way back to normal. Its importance is very early to underscore based on current limited research however, organ communication is clearly part of the systematic study of medicine as we not know it. How can we research this further? Studies to show that organs communicate with one another require randomized control trials of mice with subpar organs to see how the different other organs respond looking into the communication under homeostatic and non-homeostatic conditions. Designs should include mice with subpar organs and different blood types to mimic the human population at large. How can we do this? Please let me know if you want to research this further with me as I am a trained medical professional with limited medical expertise having finished medical studies and public health graduate coursework.